Ameliorative effect of Cassia singueana extract against acute ketamine induced cognitive impairment in murine models of schizophrenia

Introduction: In the quest for search of novel pharmacotherapy from medicinal plants psychiatric disorders, it has progressed appreciably past few decades and their therapeutic potential been evaluated in a variety murine models. Cassia singueana Del. is commonly used plant Nigeria management insanity as lactation enhancer. Aim: The main aim this study was to evaluate cognitive extract against ketamine-induced impairment mice. Methods: phytochemicals elemental minerals present were determined using standard protocol antioxidant TBA-TCAA protocols, while its oral median lethal dose (LD50) mice estimated by OECD protocol. effect (100, 200 400 mg/kg) on neurobehavioral deficit behavioural paradigms: Y- maze, object recognition, forced swim test, open field test catalepsy test. Results: phytochemical constituents alkaloids, cardiac glycosides, tannins, flavonoids, saponins, steroids triterpenes. also significantly decreased level MDA increased SOD GSH. Oral LD50 be >5000 mg/kg. (P< 0.05) exploration time percentage recognition index during retention phase NORT. Y-maze (p<0.05) number actual alternation spontaneous alternation. It duration immobility central peripheral square cross field. did not prolong induced haloperidol glass bar Conclusion: contained that could ameliorate negative symptoms schizophrenics.